AmnioNOVO™ (Amniotic Tissue Stem Cells)
AmnioNOVO™ is a pliable tissue allograft (transplant) derived from human placental amnion, which functions as a biologic structural matrix to facilitate and enhance tissue healing and repair.
Amniotic tissue has been used since 1910 in the US and is now FDA-exempt for treating wounds and other conditions. It was first used for treating eye problems, primarily corneas and is still widely used in ophthalmology today.
Once the baby is born, the placenta along with the amniotic sack and what’s left of the umbilical cord come out. It’s called afterbirth and is usually discarded.
We procure this tissue from contracted hospitals after normal, healthy births. Once it has been fully tested for infectious diseases, sterility and a few other things, the tissue is processed.Using proprietary technology, the tissue is separated into very small particles that are cryo-preserved in a special way that keeps the integrity of the tissue the same as it was when it came out after the healthy birth of the child.
The AmnioNOVO™ Advantage
- Reduces inflammation and pain
- Provides growth factors
- Supports regeneration
- Enhances stem cells
- Heals wounds
- Reduces fibrosis risk
- Reduces adhesion
- Immune privileged
AmnioNOVO™ Safety
Other than occasional pain and swelling at the injection site, we have not observed any adverse side effects from AmnioNOVO™.
The amniotic membrane is immune-privileged so the patient’s immune system can’t recognize it as a foreign substance.
The Science Behind AmnioNOVO™ for Inflammation, Pain and Wound Healing
Amniotic membrane provides structural support and a plethora of growth factors. We have identified 108 growth factors that are cryo-preserved in AmnioNOVO™. The two most important are:
- Prostaglandin
- WNT4
Prostaglandin inhibits inflammation, which occurs after injury and marks the beginning of the healing process. The faster we can tame this inflammation, the sooner the body can move on to the next phase of healing, regeneration. It’s important to note that AmnioNOVO™ has more than 60 times the amount of prostaglandin compared to other products.
WNT4 is arguably the single most important molecule required for wound healing. AmnioNOVO™ has more than 10 times the amount of WNT4 as competing products.
AmnioNOVO™ contains Interleukin-1 receptor antagonists and Tissue Inhibitor of Metallo-proteinase 1, 2, 3 and 4 proteins that suppress and modulate inflammation and subsequent pain.
The Science Behind Stem Cells, Regeneration and Growth Factors
In addition to its pain and inflammation reduction and wound healing properties, AmnioNOVO™ creates an environment that is conducive to stem cell proliferation. It contains important growth factors including PDGF, VEGF, EGF, FGF and TGF-B, which promote collagen matrix formation and cellular proliferation while minimizing the formation of scar tissue.
AmnioNOVO™ is composed of collagens and other structural proteins, which provide a biologic matrix that supports angiogenesis, tissue growth and new collagen during tissue regeneration and repair.